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Shared Resources

Biorepository and Tissue Technology


Availability of high-quality, annotated human tissue specimens and comprehensive histopathological services at the College of American Pathologists (CAP) - accredited UC San Diego Biorepository and Tissue Technology Shared Resources(BTTSR)

The BTTSR is founded on a well-established model that integrates tissue procurement, processing, storage, and multimodal (histologic, immunohistochemical, and molecular) analyses with traditional epidemiologic, clinicopathologic, and outcome parameters through a highly evolved bioinformatics system.  

The mission of the BTTSR is to support MCC, C3, and outside researchers’ projects by providing annotated human bio-specimens, and state-of-the-art histology processing, interpretation, and histopathological analysis of samples. 



We provide a wide range of services

Biorepository Services

  • Patient consenting​
  • Tissue acquisition​
    • Prospective collection ​
    • Clinical trial support​
  • Tissue storage ​
  • Distribution ​
    • Blood derivatives: Buffy Coat, Plasma, Serum, PBMC ​
    • Fresh Frozen Tissue: neoplastic and non-neoplastic ​
    • Viable freeze  ​
    • Formalin fixed paraffin embedded  Tissue: neoplastic& non-neoplastic ​
    • Formalin fixed paraffin embedded  Tissue: Autopsy ​
    • PDX Models ​
  • Other services ​
    • DNA and RNA Extraction and QA 
  • Download a Request Form for Biorepository Services

Contact Information:

Sharmeela Kaushal
Biorepository Assistant Director
Office: (858) 534-7302

Tissue Technology Services

  • Routine Histology​
    • Tissue processing and sectioning  (formalin fixed and frozen tissue)​
    • Routine H&E and specialized staining ​
  • Immunohistochemistry/Immunofluorescence​
    • Antibody optimization and validation​
    • Single and multiplexing detection assays ​
  • Whole slide scanning​
    • Brightfield AT2 Aperio​
    • Fluorescent (up to 6 channels + DAPI) PhenoImager Akoya​
  • Phenocycler Fusion: Ultra-plex Imaging​
  • Customized Tissue Micro Array (TMA) ​
  • Experimental pathology consultation​​
  • Download a Request Form for Tissue Technology Service

Contact Information:​

M. Valeria Estrada​
Tissue Technology Assistant Director​

Office: (858) 534-8607