Work under the guidance of experienced researchers to support cutting-edge cancer biology studies by assisting with the following duties:1) Perform gene manipulation in cell lines (e.g. RNAi and overexpression) to study gene function.2) Characterize resulting phenotypes through cellular assays including proliferation, migration, and cell signaling analyses.3) Isolate DNA and RNA and quantify gene expression using standard molecular biology techniques (e.g., qRT-PCR).4) Investigate RNA/RNA-binding protein interactions under cancer-relevant conditions.5) Assist with CRISPR/Cas9 and base editing approaches.6) Maintain mouse colonies and assist with transplanted tumor model experiments, including handling, monitoring, treatment, and sample collection.7) Support day-to-day lab management including onboarding new employees, ordering, inventory tracking, and equipment maintenance, and assist with additional tasks as directed by the supervising scientist.This role offers hands-on experience across a broad range of molecular and cellular techniques in a dynamic research environment.

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Working under close supervision, in a hematology/oncology research laboratory at UCSD Center for Novel Therapeutics. Assist with performing research studies and troubleshooting of new and established assay techniques. Assist with performing and analyzing in vivo and in vitro experiments to study expression of specific proteins in solid tumors and to define the role of specific proteins in promoting tumor growth, metastasis, and tumor initiation using primary cancer cells and cell lines. Assist with conducting in vivo experiments with patient-derived xenograft mouse models to assess treatment effects with novel agents. Assist with processing and banking primary human and mouse tumor samples.

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The Clinical Research Coordinator (CRC) II will coordinate and oversee start-up procedures, implementation, recruitment, screening, enrollment, and maintenance of subjects. Create informational and recruitment materials and act as a liaison with other UCSD departments and agencies for the purpose of implementation of studies. The Clinical Research Coordinator (CRC) II will plan, develop and implement start-up procedures for multiple phase I-III research studies in assigned disease team as well as lead, direct, and coordinator operational efforts. Assure compliance with state and federal regulatory guidelines. Oversee the quality of the medical and clinical research data. Provide direction and guidance to investigators. Provide education and information to the general public concerning the ongoing clinical trials. Assist PIs with proposals, progress reports and manuscripts. Independently create original documents and policies for assigned disease teams. Work closely with federal and state regulatory officials.

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Under direction of assigned Principal Investigator (PI) and Project Manager (PM), the Clinical Research Coordinator III will independently coordinate and be accountable for the overall administration of clinical research efforts for a variety of advanced research projects and clinical trials. The incumbent will provide leadership to lower level clinical research coordinators and/or other support personnel. The incumbent will be responsible for coordinating and monitoring clinical trials including providing all aspects of protocol oversight, including but not limited to screening for patient eligibility, consent review, data collection and analysis, ensuring protocol compliance, adverse drug/therapy reaction reports, monitoring patient treatment and toxicities, laboratory and specimen collection, processing, submission, and maintenance of accurate and complete clinical research files.

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