Selected Publications

Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer.  Nat Commun 16, 2964 (2025). Nakagawa, T. Luebeck, J. Zhu, K. Lange, J. Sasik, R. Phillips, C. Sadat, S. Javadzadeh, S. Yang, Q. Monther, A. Fassardi, S. Wang, A. Pestonjamasp, K. Rosenthal, B. Fisch, K. Mischel, P. Bafna, V.  Califano JA . PMID: PMC11398563. DOI: 10.21203/rs.3.rs-4636308/v1.

CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma.  Front. Immunol. 16:1528520 Sen P, Sadat S, Ebisumoto K, Al-Msari R, Miyauchi S, Roy S, Mohammadzadeh P, Lips K, Nakagawa T, Saddawi-Konefka R, Sharabi AB  Califano JA . PMID: 40475776. DOI: 10.3389/fimmu.2025.1528520.

The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapy.  Nat Commun 16, 6578 (2025). Saddawi-Konefka, R. Al Msari, R. Tang, S. Philips, C. Sadat, S. Clubb, L. Luna, S. Fassardi, S. Jones, R. Franiak Pietryga, I. Faraji, F. Schokrpur, S. Yung, B. Allevato, M. Decker, K. Nasamran, C. Chilin-Fuentes, D. Brin Rosenthal, S. Jensen, S. Fox, B. Bell, R. Gutkind, J. Sharabi,  Califano JA . PMID: 40675962. DOI: 10.1038/s41467-025-61780-4.

Defining the relationship of salivary gland malignancies to novel cell subpopulations in human salivary glands using single nucleus RNA-sequencing.  Int J Cancer. 2024 Apr 15; 154(8):1492-1503. Nakagawa T, Santos J, Nasamran CA, Sen P, Sadat S, Monther A, Bendik J, Ebisumoto K, Hu J, Preissl S, Guo T, Vavinskaya V, Fisch KM,  Califano JA . PMID: 37971144. DOI: 10.1002/ijc.34790.

A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal . Cancers (Basel). 2023 Sep 01; 15(17). Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA,   Califano JA. PMID: 37686653; PMCID: PMC10486378. DOI: 10.3390/cancers15174379.

Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma . Int J Oncol. 2021 02; 58(2):226-237. Fukusumi T, Guo TW, Ren S, Haft S, Liu C, Sakai A, Ando M, Saito Y, Sadat S,   Califano JA. PMID: 33491747; PMCID: PMC7864008. DOI: 10.3892/ijo.2020.5156.

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.  Zhou S, Kachhap S, Sun W, Wu G, Chuang A, Poeta L, Grumbine L, Mithani SK, Chatterjee A, Koch W, Westra WH, Maitra A, Glazer C, Carducci M, Sidransky D, McFate T, Verma A,   Califano JA. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-5. doi: 10.1073/pnas.0610818104. Epub 2007 Apr 24. PMID:   17456604 

MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.  Zhao Y, Ling Z, Hao Y, Pang X, Han X,   Califano JA, Shan L, Gu X. Oncotarget. 2017 Apr 11;8(15):25005-25020. doi: 10.18632/oncotarget.15334. PMID:   28212569