Selected Publications

Defining the relationship of salivary gland malignancies to novel cell subpopulations in human salivary glands using single nucleus RNA-sequencing.  Int J Cancer. 2024 Apr 15; 154(8):1492-1503. Nakagawa T, Santos J, Nasamran CA, Sen P, Sadat S, Monther A, Bendik J, Ebisumoto K, Hu J, Preissl S, Guo T, Vavinskaya V, Fisch KM,  Califano JA . PMID: 37971144. DOI: 10.1002/ijc.34790.

A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal . Cancers (Basel). 2023 Sep 01; 15(17). Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA,   Califano JA. PMID: 37686653; PMCID: PMC10486378. DOI: 10.3390/cancers15174379.

Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma . Int J Oncol. 2021 02; 58(2):226-237. Fukusumi T, Guo TW, Ren S, Haft S, Liu C, Sakai A, Ando M, Saito Y, Sadat S,   Califano JA. PMID: 33491747; PMCID: PMC7864008. DOI: 10.3892/ijo.2020.5156.

Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription . Clin Cancer Res. 2021 12 15; 27(24):6772-6786. Pang J, Nguyen N, Luebeck J, Ball L, Finegersh A, Ren S, Nakagawa T, Flagg M, Sadat S, Mischel PS, Xu G, Fisch K, Guo T, Cahill G, Panuganti B, Bafna V,   Califano J. PMID: 34548317; PMCID: PMC8710294. DOI: 10.1158/1078-0432.CCR-21-2484.

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.  Zhou S, Kachhap S, Sun W, Wu G, Chuang A, Poeta L, Grumbine L, Mithani SK, Chatterjee A, Koch W, Westra WH, Maitra A, Glazer C, Carducci M, Sidransky D, McFate T, Verma A,   Califano JA. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-5. doi: 10.1073/pnas.0610818104. Epub 2007 Apr 24. PMID:   17456604 

MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma.  Zhao Y, Ling Z, Hao Y, Pang X, Han X,   Califano JA, Shan L, Gu X. Oncotarget. 2017 Apr 11;8(15):25005-25020. doi: 10.18632/oncotarget.15334. PMID:   28212569