Overview

The Cancer Biology and Signaling Program (CBS) conducts basic research on the biological processes that underlie normal cell growth regulation and the initiation and progression of cancer. Research conducted by CBSmembers has advanced our understanding of the molecular basis and signaling pathways of cancer development and progression, which will be essential to identifying more effective prevention and treatment strategies for cancer through collaborations with translational, population, and clinical investigators.

The CBS program has 52 members across 11 departments and 3 schools. Our members investigate basic biological mechanisms that regulate cellular responses to extracellular and intracellular cues including mitogenic factors, cell death inducers, hormones, cytokines, ions, stress and differentiation factors. Our program has expanded towards understanding the molecular basis of cancer immunity to complement a major effort on cancer immunotherapy at the Moores Cancer Center. Research by the Cancer Biology and Signaling program members has made significant and comprehensive advancement to our understanding of signaling transduction in regulation of normal cell growth control. Investigators share a common research interest on bio-regulation, yet their specific research topics are along two major themes: Signal Transduction and Cell Growth and Tumorigenesis.

Program Goals

The primary goal of CBS is to maximize collaborative efforts in understanding mechanisms of cancer development and identifying novel effective drug targets in cancer treatment, with special attention to cancers that prevalently interfere with quality of life in our catchment area.