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SFG SCIENTIFIC HIGHLIGHTS

Recent Scientific Highlights from Structual & Functional Genomics Research Program members. Please contact us if you have a highlight to share.

 

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

Jeevisha Bajaj, Michael Hamilton, Yutaka Shima, Kendall Chambers, Kyle Spinler, Eric L. Van Nostrand, Brian A. Yee, Steven M. Blue, Michael Chen, David Rizzeri, Charles Chuah, Vivian G. Oehler, H. Elizabeth Broome, Roman Sasik, James Scott-Browne, Anjana RaoSTT, Gene W. YeoSFG & Tannishtha ReyaSFG

Nature Communications | 1, 410–422(2020) | https://doi.org/10.1038/s43018-020-0054-2 
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The repertoire of mutational signatures in human cancer

Ludmil B. AlexandrovSFG, Jaegil Kim, Nicholas J. Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R. Covington, Dmitry A. Gordenin, Erik N. Bergstrom, S. M. Ashiqul Islam, Nuria Lopez-Bigas, Leszek J. Klimczak, John R. McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A. Wheeler, Ville Mustonen, PCAWG Mutational Signatures Working Group, Gad Getz, Steven G. Rozen, Michael R. Stratton & PCAWG Consortium

Nature 578, 94–101 (2020). https://doi.org/10.1038/s41586-020-1943-3 
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