CBS SCIENTIFIC HIGHLIGHTS

Recent Scientific Highlights from Cancer Biology & Signaling Research Program members. Please contact us if you have a highlight to share.

Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

Tomoyuki Koga, Isaac A. Chaim, Jorge A. Benitez, Sebastian Markmiller, Alison D. Parisian, Robert F. Hevner, Kristen M. Turner, Florian M. Hessenauer, Matteo D’Antonio, Nam-phuong D. Nguyen, Shahram Saberi, Jianhui Ma, Shunichiro Miki, Antonia D. Boyer, John Ravits, Kelly A. Frazer^SFG, Vineet Bafna^SFG, Clark C. Chen, Paul S. Mischel^STT, Gene W. Yeo^SFG,Frank B. Furnari^CBS

NATURE COMMUNICATIONS | (2020)11:550 | https://doi.org/10.1038/s41467-020-14312-1 
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HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity

Qiaozhen Ye, Rebecca K Lau, Ian T Mathews, Erica A Birkholz, Jeramie D Watrous, Camillia S Azimi, Joe Pogliano, Mohit Jain^CBS, Kevin D Corbett

Mol Cell. 2020 Feb 20;77(4):709-722.e7. doi: 10.1016/j.molcel.2019.12.009. Epub 2020 Jan 10. 
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Jianhui Ma, Jorge A Benitez, Jie Li, Shunichiro Miki, Claudio Ponte de Albuquerque, Thais Galatro, Laura Orellana, Ciro Zanca, Rachel Reed, Antonia Boyer, Tomoyuki Koga, Nissi M Varki, Tim R Fenton, Suely Kazue Nagahashi, Marie Erik Lindahl, Timothy C Gahman, Andrew K Shiau, Huilin Zhou, John DeGroot, Erik P Sulman, Webster K Cavenee, Richard D Kolodner, Clark C Chen, Frank B Furnari^CBS

Cancer Cell. 2019 Mar 18;35(3):504-518.e7.doi: 10.1016/j.ccell.2019.01.020. 
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